杨友 教授，博士生导师

Email: yangyou@ecust.edu.cn

地址：上海市徐汇区梅陇路130号实验十八楼1035A室

邮编：200237

课题组网页：https://www.x-mol.com/groups/Yang_You

        杨友，必赢bwin官网登录教授，博士生导师，国家海外高层次青年人才，山东省泰山产业创新领军人才，上海市浦江人才。

        2004年毕业于中国科学技术大学化学系，获理学学士学位；随后由中国科学技术大学和中国科学院上海有机化学研究所联合培养，于2010年获中国科学技术大学理学博士学位；2014年9月至2015年8月，任必赢bwin官网登录副教授；2015年9月至今，任必赢bwin官网登录教授、博士生导师。

        中国化学会糖化学专业委员会委员、中国生化制药工业协会糖类药物专家委员会委员、中国疫苗行业协会糖疫苗专业委员会委员、上海市药学会药物化学专业委员会委员、国家药监局糖药物质量研究与评价重点实验室学术委员会委员。主要从事糖化学、糖药物和糖材料的研究。在ACS. Cent. Sci., Angew. Chem. Int. Ed., J. Am. Chem. Soc.等权威期刊发表研究论文50余篇，申请国内外发明专利10余项。获得中国药学会-施维雅青年药物化学奖、必赢bwin官网登录青年英才校长奖等奖励。

研究方向

1. 功能糖的合成和功效评价

2. 糖药物、糖疫苗和糖材料的开发

代表性论文

1. Yiyue Zhang†, Xiaotong Wang†, Youling Liang, Liangliang zhang, Jiaohao Fan, You Yang*. A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa. ACS Cent. Sci. 2024, 10, 1515–1523.

2. Xiaona Li, Cristina Di Carluccio, He Miao, Lvfeng Zhang, Jintao Shang, Antonio Molinaro, Peng Xu,* Alba Silipo,* Biao Yu, and You Yang*. Promoter-Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32-mer. Angew. Chem. Int. Ed. 2023, 62, e202307851. 

3. Rongkun Liu†, Yan Chen†, Jibin Zheng, Lvfeng Zhang, Tong Xu, Peng Xu, You Yang*. Synthesis of Nucleosides and Deoxynucleosides via Gold(I)-Catalyzed N-Glycosylation of Glycosyl (Z)-Ynenoates. Org. Lett. 2022, 24(51), 9479−9484. 

4. Liangliang Zhang†, Yiyue Zhang†, Qingting Hua, Tong Xu, Junru Liu, Yirong Zhu, You Yang*. Promoter-Controlled Synthesis and Antigenic Evaluation of Mannuronic Acid Alginate Glycans of Pseudomonas aeruginosa. Org. Lett. 2022, 24(45), 8381–8386. 

5. Xiaoqian Li†, Zhi Ma†, Rongkun Liu†, Mattan Hurevich, You Yang*. Photolabile Protecting Group-Mediated Synthesis of 2-Deoxy-Glycosides. Chin. J. Chem. 2021, 39(12), 3309–3314.

6. Junchang Wang†, Yiyue Zhang†, Yirong Zhu, Junru Liu, Yan Chen, Xin Cao, You Yang*. Total Synthesis and Immunological Evaluation of the Tri-D-glycero-D-manno-heptose Antigen of the Lipopolysaccharide as a Vaccine Candidate against Helicobacter pylori. Org. Lett. 2020, 22(22), 8780–8785. 

7. Xiaona Li, Chenyu Li, Rongkun Liu, Jiazhe Wang, Zixuan Wang, Yan Chen, You Yang*. Gold(I)-Catalyzed Glycosylation with Glycosyl Ynenoates as Donors. Org. Lett. 2019, 21(23), 9693−9698. 

8. You Yang*, Biao Yu*. Recent Advances in the Chemical Synthesis of C-Glycosides. Chem. Rev. 2017, 117(19), 12281–12356.

9. Anika Reinhardt†, You Yang†, Heike Claus, Claney L. Pereira, Andrew D. Cox, Ulrich Vogel, Chakkumkal Anish*, Peter H. Seeberger*. Antigenic Potential of a Highly Conserved Neisseria meningitidis Lipopolysaccharide Inner Core Structure Defined by Synthetic Approach. Chem. Biol. 2015, 22(1), 38–49.

10. You Yang, Shunsuke Oishi, Christopher E. Martin, Peter H. Seeberger*. Diversity-oriented Synthesis of Inner Core Oligosaccharides of the Lipopolysaccharide of Pathogenic Gram-negative Bacteria. J. Am. Chem. Soc. 2013, 135(16), 6262–6271. 

11. You Yang, Christopher E. Martin, Peter H. Seeberger*. Total Synthesis of the Core Tetrasaccharide of Neisseria meningitidis Lipopolysaccharide, a Potential Vaccine Candidate for Meningococcal Diseases. Chem. Sci. 2012, 3(3), 896–899. 

12. You Yang, Yao Li, Biao Yu*. Total Synthesis and Structure Revision of TMG-chitotriomycin, a Specific Inhibitor of Insect and Fungal β-N-Acetylglucosaminidases. J. Am. Chem. Soc. 2009, 131(34), 12076–12077.