研究方向
--------------------------------------------------------------------------------
主要研究领域：制药工程与技术；合成药物化学
主要研究方向：
1 重点药物品种的合成工艺研究
2 药物绿色高效合成方法研究
3 基于临床和绿色高效合成方法的药物（抑郁症、感染性疾病和癌症等疾病治疗药物）设计与合成
方法学研究标新立异；产业化项目简易实用；药物发现着眼于临床，趋于定向。热诚欢迎国内外企业和科研院所合作研究；热诚欢迎具有良好有机合成基础、有志于从事新药研究和药物合成工艺研究的有志之士来本实验室攻读硕士、博士学位，或进行博士后研究！
获奖成果
--------------------------------------------------------------------------------
国家新药证书，国家授权专利，上海市工业园区理工教师创新奖，上海市教学成果一等奖（5），必赢bwin官网登录教学成果一等奖，必赢bwin官网登录育英奖一等奖等。
代表性论著
--------------------------------------------------------------------------------
(1) Zhang, Huiwen; Ma, Chunmei; Zheng, Ziwei; Sun, Rengwei; Yu, Xinhong*; Zhao, Jianhong*. Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction. Chem. Commun.，2018, 54, 4935-4938.
(2) Tang, Mi; Sun, Rengwei; Li, Hao; Yu, Xinhong*; Wang, Wei*. An Unconventional Redox Cross Claisen Condensation–Aromatization of 4-Hydroxyprolines with Ketones. J. Org. Chem.，2017, 82, 8419-8425.
(3) Sun, Rengwei; Song, Wei; Ma, Chunmei; Zhang, Huiwen; Yu, Xinhong*. Titanium(IV) Chloride-Mediated Stereoselective α-Alkylidenation to Efficiently Assemble Multisubstituted 1,3-Dienes. Adv. Synth. Catal.，2016, 358, 3977-3982.
(4) Song, Guangjun; Zheng, Ziwei; Wang, Yanhui; Yu, Xinhong*. Pd-Catalyzed Site-Selective p-Hydroxyphenyloxylation of Benzylic α-C(sp3)–H Bonds with 1,4-Benzoquinone. Org. Lett.，2016, 18, 6002-6005.
(5) Tang, Mi; Tong, Lingfeng; Ju, Lei; Zhai, Wanwan; Hu, Yang; Yu, Xinhong*. Benzoic Acid Catalyzed Annulations of α-Amino Acids and Aromatic Aldehydes Containing an ortho-Michael Acceptor: Access to 2,5-Dihydro-1H-benzo[c]azepines and 10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a]azepines. Org. Lett.，2015, 17, 5180-5183.
(6) Hu, Yang; Ma, Yueyue; Sun, Rengwei; Yu, Xinhong*; Xie, Hexin*; Wang, Wei*. Amine-Catalyzed Highly Regioselective and Stereoselective C(sp2)-C(sp2) Cross-Coupling of Naphthols withtrans-α,β-Unsaturated Aldehydes. Chemistry - An Asian Journal，2015, 10, 1859-1863.
(7) Hu, Yang; Ju, Lei; Lu, Lin; Ma, Hongmei; Yu, Xinhong*. Stereoselective α-indolylation of enals via an organocatalytic formal cross-coupling with indoles. Org. Biomol. Chem.，2015, 13, 8869-8874.
(8) Xu Zian,Zhai WanWan, Feng CongPeng, Liu Hongwei*, Zhao JianHong * and Yu Xinhong*.Water-mediated three-component Wittig-SNAr Reactions. Synlett, 2015, 26, 820-826.
(9) Xu Zian，Ge Jingying，Wang Tianchi, Luo Ting, Liu Hongwei* and Yu Xinhong*. Highly Stereoselective Synthesis of 2-Aminobenzylidene Derivatives by A Convergent 3-Component Approach. Synlett, 2014, 25, 2913-2917.
(10) Zou Zhiqin, Deng Zejun, Yu Xinhong*, Zhang Manman, Zhao Sihan, Luo Ting, Yin Xin, Xu Hui and Wang Wei*. A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes. Science China–Chem, 2012, 55(1), 43-49.
(11) Xie Hexin, Zhang Shilei*, Li Hao, Zhang Xinshuai, Zhao Sihan, Xu Zian, Song Xixi, Yu Xinhong*, Wang Wei*. Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols. Chem. Eur. J, 2012, 18(8),2230-2234.
(12) Zhang Xishuai, Song Xixi, Li Hao, Zhang Shilei, ChenXiaobei, Yu Xinhong*and Wang Wei*. Efficient synthesis of poly-substituted quinolines and chiral 1,4-dihydroquinolines by an organocatalytic cascade approach. An unanticipated effect of “N” protecting groups on formed products . Angew. Chem. Int. Ed., 2012, 51,7282-7286.
(13) Wang Jian, Zhang Manman, Zhang Shieli, Xu ZiAn, Li Hao, Yu Xinhong*, Wang Wei*. Chiral pyrrolidine sulfonamide catalyzed enantioselective Michael addition of cyclohexanones to maleimides. Synlett, 2011, (4): 473-476.
(14) Zhang Shilei, Xie Hexin, Song Aiguo, Wu Deyan, Zhu Jin, Zhao Sihan, Li Jian*, Yu Xinhong* and Wang Wei*. Efficient preparation of trans-α,β-unsaturated aldehydes from saturated aldehydes by oxidative enamine catalysis. Science China–Chem, 2011, 54(12), 1932-1936.
(15) Yu Xinhong, Wang Wei *. Organocatalysis: asymmetric cascade reactions catalysed by chiral secondary amines. Org. Biomol. Chem., 2008, 6(12), 2037-2046. 该论文作为封面介绍.
(16) Yu Xinhong, Wang Wei *. Hydrogen-bond-mediated asymmetric catalysis. Chem. Asian J.,2008, 3(3): 516-532.
(17) Zu Liansuo, Xie Hexin, Li Hao, Wang Jian, Yu Xinhong*, Wang Wei*. Chiral amine catalyzed enantioselective cascade aza-ene-type cyclization reactions. Chem. Eur. J., 2008, 14(21),6333-6335.
(18) Xu Hui, Yu Xinhong*, Sun Leying, Liu Jing, Fan Wen, Shen Yongjia*,Wang Wei *. Microwave-assisted three-component Knoevenagel-nucleophilic aromatic substitution reactions. Tetrahedron Lett., 2008, 49(32):4687-4689.
(19) Zu Liansuo, Li Hao, Wang Jian, Yu Xinhong*, Wang Wei*. Highly enantioselective aldehyde-nitroolefin Michael addition reactions catalyzed by recyclable fluorous (S) diphenylpyrrolinol silyl ether. Tetrahedron Lett., 2006, 47(29): 5131-5134.
(20) Yu Xinhong. Rational drug synthesis based on green efficient synthetic mothodologies. The 6th International Symposium for Chinese Medicinal Chemists. July 28-August 2, 2008, OP-11/93.
(21) Wang Jian, Li Hao, Yu Xinhong, Zu Liansuo, Wang Wei*.Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction.Org. Lett., 2005, 7(19): 4293-4296. 该工作是Org. Lett. 2005, 2006 和2007 年的“热点文章”和“引用率最高”的论文之一.
发明专利：
1. 虞心红，邹志芹，张曼曼，邓泽军，罗婷，徐子安，徐辉。吡咯衍生物的制备方法[P]. 中国发明专利：ZL 2011 1 0040281.X，授权公告日：2012-11-14.
2. 虞心红，殷昕，刘建文，张曼曼，刘连军，李义全具有抗肿瘤作用的二元羧酸双（异羟肟酸）酯及制备方法. 中国发明专利：ZL 2011 1 0357871.5，授权公告日：2015-2-25..
3. 虞心红，刘连军，张曼曼，刘建文，罗婷，程卓安。具有抗肿瘤作用的二元羧酸衍生物及制备方法. 中国发明专利：ZL 2011 1 0305131.7，授权公告日：2014-6-11.
4. 虞心红，张曼曼，刘连军，刘建文，程卓安。异羟肟酸的二元羧酸单酯衍生物的抗肿瘤作用和制备方法. 中国发明专利：ZL 2011 1 0054331.X，授权公告日：2014-7-16.
5. 虞心红，张曼曼，徐辉，徐子安，刘连军，金惠。具有抗肿瘤作用的N-苯基-N’-(末端羧酸取代酰氧基)辛二酰胺类化合物及其药用盐[P]. 中国发明专利：ZL 2011 1 0054331.X，授权公告日：2014-7-16.
6. 虞心红，张卫东，谈遂初，吕和平，刘金平，毛庆华，赵恒，沈永嘉，傅收，王伟，黄文超。一种制备N-芳酰基-L-谷氨酸的方法[P]. 中国发明专利：ZL 03 1 28982.7，授权公告日2006-03-29.
7. 虞心红，张延锋，彭艺阁，郑蓉，侯志安，林童，徐书海，沈永嘉，田禾。生物前药咪唑[1,2-a]并吡啶卤化物及其制备方法[P]. 中国发明专利ZL 01 1 12825.9，授权公告日2005-03-23.
