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个人简介

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        徐文平，1967年2月生，上海徐汇人。博士，教授，研究生导师，农业农村部农药生物活性室内测试行业标准的主要起草人。1985年毕业于上海七宝中学，1989年毕业于华东化工学院（现必赢bwin官网登录）生物化学专业，2009年获南京师范大学微生物专业理学博士学位。1989年至2009年工作于上海市农药研究所，2010年调入必赢bwin官网登录。1989年至今，先后承担和参与了生物农药领域的多个重要研究项目，包括国家“九五”、“十五”科技攻关计划和“十一五”、“十二五”的科技支撑计划课题、“十三五”、“十四五”重点研发计划项目以及上海市政府重点科技攻关项目等，同时也承担了多项企业委托课题，获国内外发明专利授权30余件，近十年在农药领域国内外期刊发表论文70余篇。

研究方向

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近三年主要论著（2017-2020）

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[1]     Youwu Hao, Yang Zhang, Jiagao Cheng, Wenping Xu, Zhiping Xu, Jufang Gao, Liming Tao*. Adjuvant contributes Roundup's Unexpected Effects on A549 Cells. Environ. Res.2020,184, 109306

       [2]     张颂函，杨星，占秀萍，张乐山，徐文平*. 上海地区田间菜蚜对啶虫脒的抗性研究[J]. 农药，2019, 58(07), 540-542.

[3]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Zhiping Xu, Liming Tao, Zhong Li*, Wenping Xu*. Spinetoram confers its cytotoxic effects by inducing AMPK/mTOR-mediated autophagy and oxidative DNA damage. Ecotoxicol. Environ. Saf. 2019, 183, 109480.

[4]     Yang Zhang^#, Wei Guo^#, Hui Chen, Jufang Gao, Liming Tao, Zhong Li*, Wenping Xu*. The cytotoxic effects of spinetoram on human HepG2 cells by inducing DNA damage and mitochondria-associated apoptosis. Food Agric. Immunol. 2019, 30, 1020-1032.

[5]     Yang Zhang, Yangyang Fan, Jufang Gao, Wenping Xu, Zhiping Xu, Yutian Liu, Zhong Li*, Liming Tao*. A new 24-membered macrolide shows insecticidal activity against Pieris rapae potentially through induction of programmed cell death. Food Agric. Immunol. 2019, 30, 727-742.

[6]     Yang Zhang, Hui Chen, Yangyang Fan, Yun Yang, Jufang Gao, Wenping Xu, Zhiping Xu, Zhong Li*, Liming Tao*. Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.Chemosphere. 2019, 230, 182-189.

[7]     Yangyang Fan^#, Yang Zhang^#, Yutian Liu, Wenping Xu, Yun Yang, Youwu Hao, Liming Tao*. A natural product enhances apoptosis via mitochondria/caspase-mediated pathway in Hela cells.J. Cell Biochem. 2019, 120(10), 16811-16823.

[8]     Youwu Hao^#, Yang Zhang^#, Hongfei Ni, Jufang Gao, Yun Yang, Wenping Xu, Liming Tao*. Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung and nerve. J. Environ Sci. Heal, B. 2019, 54(9), 737-744.

[9]     Youwu Hao^#, Yang Zhang^#, Wenping Xu, Jufang Gao, Liming Tao*. Synergistic effects of adjuvant A-134 on the herbicidal effects of glyphosate. J. Pestic. Sci.2019,44(4), 249-254.

[10]Ping Zhang, Yang Zhang, Kuikui Liu, Bin Liu, Wenping Xu, Jufang Gao, Lei Ding, Liming Tao*. Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway. Cell Proliferat. 2019, 52(2), e12543.

[11]Youwu Hao, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Roundup® induced AMPK/mTOR mediated autophagy in human A549 cells. J. Agric. Food Chem.2019,67, 11364-11372.

[12]Youwu Hao, Nan Zhang, Wenping Xu, Jufang Gao, Yang Zhang,Liming Tao*. A natural adjuvant shows the ability to improve the effectiveness of glyphosate application. J. Pestic. Sci.2019,44(2), 106-111.

[13]Youwu Hao, Hui Chen, Wenping Xu, Jufang Gao, Yun Yang, Yang Zhang, Liming Tao*. Roundup® confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction. Environ. Pollut. 2019,252A, 917-923.

[14]Haijing Cao, Wenjing Liu, Yuansen Chang, Hui Chen, Yang Zhang, Wenping Xu, Liming Tao*. 5′-Epi-SPA-6952A, a new insecticidal 24-membered macrolide produced by Streptomyces diastatochromogenes SSPRC-11339. Nat. Prod. Res. 2019, 33(5), 659-664.

[15]Yang Zhang, Yuansen Chang, Haijing Cao, Wenping Xu, Zhong Li, Liming Tao*. Potential threat of chlorpyrifos to human liver cells via the caspase-dependent Mitochondrial Pathways.  Food Agric. Immunol. 2018, 29, 294-305.

[16]Yun Yang, Wenjing Liu, Jian Wang, Yang Zhang, Wenping Xu, Liming Tao*. The different effects of natural pyrethrins and beta-cypermethrin on human hepatocyte QSG7701 cells by ROS-mediated oxidative damage. Environ. Sci. Pollut. R. 2018, 25(24), 24230-24240.

[17]Yun Yang, Jufang Gao, Yang Zhang, Wenping Xu, Youwu Hao, Zhiping Xu, Liming Tao*. Natural pyrethrins induce autophagy of HepG2 cells through the activation of AMPK/mTOR pathway. Environ. Pollut. 2018, 241, 1091-1097.

[18]Wenping Xu^#, Mingjun Yang^#, Jufang Gao, Yang Zhang, Liming Tao*. Oxidative stress and DNA damage induced by spinosad exposure in Spodoptera frugiperda Sf9 cells. Food Agric.Immunol. 2018, 29, 171-181.

       [19]郭俊夫，宗蜜蜜，徐文平，陶黎明*. 海洋链霉菌P10-16代谢产物的分离与鉴定[J]. 湖南农业大学学报(自然科学版)，2017, 43(06), 615-619.

       [20]程亮，罗明明，吴继纲，郝有武，徐文平，陶黎明*. 海洋放线菌Y12-26中抗真菌活性代谢产物的分离纯化与结构鉴定[J]. 中国抗生素杂志，2017, 42(08), 631-638.

       [21]杨韵，卢淼青，张阳，杨明俊，徐文平，陶黎明*. 高效氯氰菊酯对草地贪夜蛾Sf9细胞自噬的诱导作用[J]. 农药学学报，2017, 19(02), 176-181.

[22]Yang Zhang, Jigang Wu, Wenping Xu, Jufang Gao, Haijing Cao, Mingjun Yang, Bo Wang, Youwu Hao, Liming Tao*. Cytotoxic effects of avermectin on human HepG2 cells in vitro bioassays. Environ. Pollut. 2017, 220, 1127-1137.

[23]Mingjun Yang, Bo Wang, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces programmed cell death involves mitochondrial dysfunction and cytochrome c release in Spodoptera frugiperda Sf9 cells. Chemosphere. 2017, 169, 155-161.

[24]Yun Yang, Mimi Zong, Wenping Xu, Yang Zhang, Bo Wang, Mingjun Yang, Liming Tao*. Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway. Chem-Biol. Interact. 2017, 262, 38-45.

[25]Wenping Xu^#, Bo Wang^#, Mingjun Yang, Yang Zhang, Zhiping Xu, Yun Yang, Haijing Cao, Liming Tao*. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ. Toxicol Phar. 2017, 49, 89-96.

[26]Youwu Hao, Gaohui Zhou, Wei Wu, Yang Zhang, Liming Tao, Jianhua Yao, Wenping Xu*. Synthesis and antiviral evaluation of novel N-6 substituted adenosine analogues. Tetrahedron Lett. 2017, 58(3), 190-193.

[27]Mingjun Yang, Youwu Hao, Jufang Gao, Yang Zhang, Wenping Xu, Liming Tao*. Spinosad induces autophagy of Spodoptera frugiperda Sf9 cells and the activation of AMPK/mTOR signaling pathway. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. 2017, 195, 52-59.

[28]Wenping Xu^#, Songlin Liu^#, Yang Zhang, Jufang Gao, Mingjun Yang, Xiao Liu, Liming Tao*. Cypermethrin resistance conferred by increased target insensitivity and metabolic detoxification in Culex pipiens pallens Coq. Pestic. Biochem. Physiol. 2017, 142C, 77-82.

[29]Zhiping Xu, Miaoqing Lu, Mingjun Yang, Wenping Xu, Jufang Gao, Yang Zhang, Yun Yang, Liming Tao*. Pyrethrum-extract induced autophagy in Insect cells: A new target? Pestic. Biochem. Physiol. 2017, 137, 21-26.

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1.  CTBS蛋白作为精卵结合受体的靶点在筛选精卵结合抑制剂中的应用，2013年，中国发明专利，授权公告号 CN 103743910 B；

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