张健 特聘研究员/副教授 博士生导师
E-mail: zhangjian7@ecust.edu.cn
通讯地址：上海市徐汇区梅陇路130号实验18楼723室；邮编：200237
个人简介：
本科（2009年7月）毕业于河北大学生物科学专业；2014年毕业于中国科学院大学生物化学与分子生物学专业，获得理学博士学位。2014年至2016年，在中国科学院生命科学研究院营养科学研究所从事博士后工作；2016年底，人才引进到天津医科大学，基础医学院药理系副教授、硕士生导师；2021年12月至今，必赢bwin官网登录药物科学系，特聘研究员/副教授，博士生导师。
作为项目负责人主持国家自然科学基金面上项目、国家自然科学基金青年项目、京津冀基础研究合作专项、天津市自然科学基金等，作为项目骨干参与国家重点研发计划等。曾获2021年度华夏医学科技奖二等奖（第三完成人）；2018年天津市青年人才托举工程；2018年天津市创新人才推进计划青年科技优秀人才；2017年天津市131创新型人才培养工程。主要学术兼职包括天津院士专家工作发展促进会理事；中国青年科技工作者协会第六届生物医药专委会会员；《血管生物学》编委，Frontiers in Pharmacology期刊副主编等。
研究方向：
心血管疾病及相关代谢综合征的疾病机制研究和新靶标的发现。
近五年代表性论文：
1. Fangdi Zou, Yong Li, Shijie Zhang, Jian Zhang*. DP1 Activation Protects Against Vascular Remodeling and VSMC Transition to Myofibroblasts in Angiotensin II-induced Hypertension in Mice. Hypertension. 2021 Jan 31th Accepted.（心血管国际顶级期刊）
2.Daile Jia, Peiyuan Bai, Naifu Wan, Jiao Liu, Qian Zhu, Yuhu He, Guilin Chen, Jing Wang, Han Chen, Chen Wang, Ankang Lyu, Michael Lazarus, Yunchao Su, Yoshihiro Urade, Ying Yu*, Jian Zhang*, Yujun Shen*. Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages.Circulation Research. 2020;127:1323–1336. （心血管国际顶级期刊）
3. Shumin Guo, Rui Zhang, Qian Liu,Qiangyou Wan, Yuanyang Wang, Yu Yu, Guizhu Liu, Yujun Shen, Lijian Hui, Ying Yu, Jian Zhang*. 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice through c-Jun activation. FASEB J. 2019;33(9):10207-10217.
4.Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang*, Ying Yu*. Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice. Brit J Pharmacol. 2018; 175:1205–1216. （药理学顶级期刊）
5. Guizhu Liu, Yanjun Gong, Rui Zhang, Lingjuan Piao, Xinzhi Li, Qian Liu, Shuai Yan, Yujun Shen, Shumin Guo, Mingjiang Zhu, Huiyong Yin, Colin D. Funk, Jian Zhang*, Ying Yu*. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration.FASEB J. 2018; 32(10):5413-5425.
6. Mulin Jun Li#, Jian Zhang#, Jiexing Wu, Peng Jiang, Wei Li, Yun Zhu, Daniel Fernandez, Russell J. H. Ryan, Yiwen Chen , Junwen Wang , Jun S. Liu, X. Shirley Liu. Exploring genetic associations with ceRNA regulation in the human genome. Nucleic Acids Research. 2017 Jun 2;45(10):5653-5665.（生物学TOP期刊）
7. Jian Zhang, Fangfang Zou, Juan Tang, Qianqian Zhang, Yanjun Gong, Qingsong Wang, YujunShen, Lixia Xiong, Richard M. Breyer, Michael Lazarus, Colin D. Funk, Ying Yu. Cyclooxygenase-2–derived prostaglandin E2 promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor. Circulation Research. 2013;113(2):104-114. （心血管领域国际顶级期刊）
7. Jian Zhang, Yanjun Gong, Ying Yu. PGF2alpha receptor: a promising therapeutic target for cardiovascular disease.Frontiers in Pharmacology. 2010; 1(116):1-7.
8. Yu Hu He, Xiao Qun Wang,Jian Zhang,Zhu Hui Liu, Wen Qi Pan, Ying Shen, Zheng Bin Zhu, Ling Jie Wang, Xiao Xiang Yan, Ke Yang, Rui Yan Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu. Association of serum HMGB2 levels with in-stent restenosis: HMGB2 promotes neointima hyperplasia in mice with femoral artery injury and proliferation and migration of VSMCs. Arteriosclerosis Thrombosis and Vascular Biology. 2017 Apr;37(4):717-729. （血液学TOP期刊）
9. Guilin Chen, Shengkai Zuo, Juan Tang, Caojian Zuo, Daile Jia, Qian Liu, Guizhu Liu, Qian Zhu, Yuanyang Wang, Jian Zhang, Yujun Shen, Dongrui Chen, Ping Yuan, Zhiqiang Qin, Chengchao Ruan, Jue Ye, Xiao-Jian Wang, Yuping Zhou, Pingjin Gao, Peng Zhang, Jinming Liu, Zhi-Cheng Jing, Ankang Lu, Ying Yu*. Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018; 215(8):2175-2195.
10. Shengkai Zuo, Deping Kong, Chenyao Wang, Jiao Liu, Yuanyang Wang, Qiangyou Wan, Shuai Yan, Jian Zhang, Juan Tang, Qianqian Zhang, Luheng Lyu, Xin Li, Zhixin Shan, Li Qian, Yujun Shen*, Ying Yu*. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyteapoptosis through m-calpain. EMBO Mol Med.2018; 10(3). pii: e8237.
11. Juan Tang, Yujun Shen, Guilin Chen, Qiangyou Wan, Kai Wang, Jian Zhang, Jing Qin, Guizhu Liu, Shengkai Zuo, Bo Tao, Yu Yu, Junwen Wang, Michael Lazarus, Ying Yu*. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat Commun. 2017; 8:14656.
12. Di Chen, Juan Tang, Qiangyou Wan, Jian Zhang, Kai Wang, Yujun Shen*, Ying Yu*. E-prostanoid 3 receptor mediates sprouting angiogenesis through suppression of the protein kinase A/β-catenin/Notch pathway. Arterioscler Thromb Vasc Biol. 2017; 37(5):856-866. （血液学TOP期刊）
